An absolute interval scale of order for point patterns

Human observers readily make judgements about the degree of order in planar arrangements of points (point patterns). Here, based on pairwise ranking of 20 point patterns by degree of order, we have been able to show that judgements of order are highly consistent across individuals and the dimension of order has an interval scale structure spanning roughly 10 just-notable-differences (jnd) between disorder and order. We describe a geometric algorithm that estimates order to an accuracy of half a jnd by quantifying the variability of the size and shape of spaces between points. The algorithm is 70% more accurate than the best available measures. By anchoring the output of the algorithm so that Poisson point processes score on average 0, perfect lattices score 10 and unit steps correspond closely to jnds, we construct an absolute interval scale of order. We demonstrate its utility in biology by using this scale to quantify order during the development of the pattern of bristles on the dorsal thorax of the fruit fly.     

Perceptions of Neighbourhood Disorder and Reputation: Qualitative Findings from Two Contrasting Areas of an Australian City

Within Australian cities, social and economic inequalities manifest themselves spatially. Perceived neighbourhood disorder and neighbourhood reputation are relevant to considering the ways in which social and economic inequalities translate into place-based inequalities. This article explores the ways in which residents of two socio-economically contrasting urban areas describe and explain neighbourhood disorder and neighbourhood reputation. It draws upon qualitative data from 40 in-depth interviews, in addition to quantitative data from a postal survey. The qualitative findings highlighted how issues of neighbourhood disorder and reputation were intertwined. In both areas, participants sought to portray themselves and their neighbourhoods in positive ways, by attributing responsibility for neighbourhood disorder to people who were unlike themselves, and by highlighting places that were perceived to have worse reputations and higher levels of disorder. The findings are considered in light of Bourdieu's theory of capitals. This article indicates that both neighbourhood disorder and reputation are pathways through which social, economic and health inequities are maintained in urban areas.     

Diesel exhaust particles modulate the tight junction protein occludin in lung cells in vitro

Background  

Using an in vitro triple cell co-culture model consisting of human epithelial cells (16HBE14o-), monocyte-derived macrophages and dendritic cells, it was recently demonstrated that macrophages and dendritic cells create a transepithelial network between the epithelial cells to capture antigens without disrupting the epithelial tightness. The expression of the different tight junction proteins in macrophages and dendritic cells, and the formation of tight junction-like structures with epithelial cells has been demonstrated. Immunofluorescent methods combined with laser scanning microscopy and quantitative real-time polymerase chain reaction were used to investigate if exposure to diesel exhaust particles (DEP) (0.5, 5, 50, 125 μg/ml), for 24 h, can modulate the expression of the tight junction mRNA/protein of occludin, in all three cell types.     

Accelerated Visualization of Dynamic Molecular Surfaces

Molecular surfaces play an important role in studying the interactions between molecules. Visualizing the dynamic behavior of molecules is particularly interesting to gain insights into a molecular system. Only recently it has become possible to interactively visualize dynamic molecular surfaces using ray casting techniques. In this paper, we show how to further accelerate the construction and the rendering of the solvent excluded surface (SES) and the molecular skin surface (MSS). We propose several improvements to reduce the update times for displaying these molecular surfaces. First, we adopt a parallel approximate Voronoi diagram algorithm to compute the MSS. This accelerates the MSS computation by more than one order of magnitude on a single core. Second, we demonstrate that the contour‐buildup algorithm is ideally suited for computing the SES due to its inherently parallel structure. For both parallel algorithms, we observe good scalability up to 8 cores and, thus, obtain interactive frame rates for molecular dynamics trajectories of up to twenty thousand atoms for the SES and up to a few thousand atoms for the MSS. Third, we reduce the rendering time for the SES using tight‐fitting bounding quadrangles as rasterization primitives. These primitives also accelerate the rendering of the MSS. With these improvements, the interactive visualization of the MSS of dynamic trajectories of a few thousand atoms becomes for the first time possible. Nevertheless, the SES remains a few times faster than the MSS.     

Inherent and apparent scattering properties of coated or uncoated spheres embedded in an absorbing host medium

The conventional Lorenz-Mie formalism is extended to the case for a coated sphere embedded in an absorbing medium. The apparent and inherent scattering cross sections of a particle, derived from the far field and near field, respectively, are different if the host medium is absorptive. The effect of absorption within the host medium on the phase-matrix elements associated with polarization depends on the dielectric properties of the scattering particle. For the specific cases of a soot particle coated with a water layer and an ice sphere containing an air bubble, the phase-matrix elements -P12/P11 and P33/P11 are unique if the shell is thin. The radiative transfer equation for a multidisperse particle system embedded within an absorbing medium is discussed. Conventional multiple-scattering computational algorithms can be applied if scaled apparent single-scattering properties are applied.     

CAD/CAM技术在脚医学中的应用

将CAD／CAM技术与脚医学结合，研究开发脚支撑设计制造系统，包括脚底曲面数据的读取及处理，根据医疗规划完成三维脚支撑模型的构造，平衡及光滑处理，激光快速原型文件和铣削加工刀具轨迹的自动生成等。     

Apolipoprotein E isoforms in Alzheimer's disease pathology and etiology

The apolipoprotein E (apoE) epsilon4 allele increases risk of Alzheimer's disease (AD), perhaps by accelerating plaque formation, or by impairing neuron repair. Considerable evidence supports both mechanisms. AD patients with epsilon4 have more and earlier amyloid deposits than do patients without epsilon4. The same is true of non-demented control subjects. In vitro, all apoE isoforms inhibit amyloid beta protein (Abeta) aggregation, but apoE4 less effectively than apoE3. Transgenic amyloid-producing mice expressing apoE3 or apoE4 develop less Abeta deposition than apoE knockout mice. These observations are consistent with an effect of apoE isoforms on Abeta aggregation in AD. ApoE is important for neurite maintenance since apoE knockout mice lose neurites and suffer behavioral deficits with aging or treatment with excitotoxins. ApoE4 mice show similar defects, but apoE3 mice are normal. AD patients with epsilon4 show more neuritic deficits than epsilon3 carriers. ApoE epsilon4 also worsens neurological impairment in head injury, stroke, and multiple sclerosis. Thus, apoE4 is less effective at neurite maintenance. Perhaps epsilon4 increases AD risk by both mechanisms: allowing amyloid deposition and failing to repair neurites. In either case, introducing apoE3 or apoE2 into the brain, for example by gene therapy or cell grafts, might delay AD progression.     

Communication during marital conflict: When couples alter their appraisal, they change their behavior.

In a sample of 77 recently married couples, within-person variance in cognitive appraisal was expected to predict corresponding within-person variance in communication behavior during conflict. Three types of appraisal were considered: expectancies of partner understanding, expectancies of partner negative communication, and attributions. Couples were observed in 4 different conflict conversations, completed during 2 assessment sessions, and appraisals were assessed prior to each conversation. Hierarchical linear modeling was used to analyze within-person effects. Changes from one conversation to the next in all 3 types of appraisal predicted corresponding within-person change in communication, and many effects were larger for wives than for husbands. Results were strongest for expectancies of partner understanding. Expectancies predicted change in one's own behavior after controlling for the accuracy of the expectancy. (PsycINFO Database Record (c) 2011 APA, all rights reserved)